![]() ![]() ![]() A poor association between symptoms and lesion localization was found, indicating existing comorbidity between endometriosis and irritable bowel syndrome (IBS). The majority of endometriosis patients experience more severe gastrointestinal symptoms than controls. Initiation of either combined oral contraceptives or progesterone for endometriosis had no effect on gastrointestinal symptoms when the patients were followed prospectively. Patients using opioids experienced more severe symptoms than patients not using opioids, and patients with current or previous use of GnRH analogs had more severe abdominal pain than the other patients ( P = 0.024). Half of the patients were able to differentiate between abdominal pain from endometriosis and from the gastrointestinal tract. The symptoms were not associated with menstruation or localization of endometriosis lesions, except increased nausea and vomiting ( P = 0.010) in patients with bowel-associated lesions. Compared to controls, patients with endometriosis experienced significantly aggravated abdominal pain ( P = 0.001), constipation ( P = 0.009), bloating and flatulence ( P = 0.000), defecation urgency ( P = 0.010), and sensation of incomplete evacuation ( P = 0.050), with impaired psychological well-being ( P = 0.005) and greater intestinal symptom influence on their daily lives ( P = 0.001). ResultsĪ total of 109 patients and 65 controls were investigated. Data were compared to a control group from the general population. Gastrointestinal symptoms were registered using the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) socioeconomic and medical histories were compiled using a clinical data survey. MethodsĪll patients with diagnosed endometriosis at the Department of Gynecology were invited to participate in the study. The aims of the present study were to investigate gastrointestinal symptoms among patients with endometriosis and to examine whether symptoms were associated with menstruation, localization of endometriosis lesions, or treatment with either opioids or GnRH analogs, and if hormonal treatment affected the symptoms. Gonadotropin-releasing hormone (GnRH) analogs are used to treat endometriosis however, some patients develop gastrointestinal dysmotility following this treatment. Women with endometriosis often experience gastrointestinal symptoms.
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